Progesterone modulates cell growth via integrin αvβ3-dependent pathway in progesterone receptor-negative MDA-MB-231 cells.

ABSTRACT: Progesterone (P₄) plays a pivotal role in regulating the cancer progression of various types, including breast cancer, primarily through its interaction with the P₄ receptor (PR). In PR-negative breast cancer cells, P₄ appears to function in mediating cancer progression, such as cell growth. However, the mechanisms underlying the roles of P₄ in PR-negative breast cancer cells remain incompletely understood. This study aimed to investigate the effects of P₄ on cell proliferation, gene expression, and signal transduction in PR-negative MDA-MB-231 breast cancer cells. P₄-activated genes, associated with proliferation in breast cancer cells, exhibit a stimulating effect on cell growth in PR-negative MDA-MB-231 cells, while demon

SUBMITTER: Tsai CC 

PROVIDER: S-EPMC11283053 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature