Topological Perturbations in the Functional Connectome Support the Deficit/Non-deficit Distinction in Antipsychotic Medication-Naive First Episode Psychosis Patients.

ABSTRACT:

Background

Heterogeneity in the etiology, pathophysiology, and clinical features of schizophrenia challenges clinicians and researchers. A helpful approach could be stratifying patients according to the presence or absence of clinical features of the deficit syndrome (DS). DS is characterized by enduring and primary negative symptoms, a clinically less heterogeneous subtype of the illness, and patients with features of DS are thought to present abnormal brain network characteristics, however, this idea has received limited attention. We investigated functional brain network topology in patients displaying deficit features and those who do not.

Design

We applied graph theory analytics to resting-state functional magnetic resonance imaging data of 61 antipsychotic medication-n

SUBMITTER: Teles M 

PROVIDER: S-EPMC11283198 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature