Sequence Similarity among Structural Repeats in the Piezo Family of Mechanosensitive Ion Channels.

ABSTRACT: Members of the Piezo family of mechanically activated cation channels are involved in multiple physiological processes in higher eukaryotes, including vascular development, cell differentiation, touch perception, hearing, and more, but they are also common in single-celled eukaryotic microorganisms. Mutations in these proteins in humans are associated with a variety of diseases, such as colorectal adenomatous polyposis, dehydrated hereditary stomatocytosis, and hereditary xerocytosis. Available 3D structures for Piezo proteins show nine regions of four transmembrane segments each that have the same fold. Despite the remarkable similarity among the nine characteristic structural repeats in the family, no significant sequence similarity among them has been reported. Using bioinformatics appr

SUBMITTER: Hendargo KJ 

PROVIDER: S-EPMC11283329 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature