Grading urothelial carcinoma with probe-based confocal laser endomicroscopy during flexible cystoscopy.

ABSTRACT:

Purpose

Urothelial bladder cancer (UCB) care requires frequent follow-up cystoscopy and surgery. Confocal laser endomicroscopy (CLE) is a probe-based optical technique that can provide real-time microscopic evaluation with the potential for outpatient grading of UCB. This study aims to investigate the diagnostic accuracy and interobserver variability for the grading of UCB with CLE during flexible cystoscopy (fCLE).

Methods

Participants scheduled for transurethral resection of papillary bladder tumors were prospectively included for intra-operative fCLE. Exclusion criteria were flat lesions, fluorescein allergy or pregnancy. Two independent observers evaluated fCLE, classifying tumors as low- or high-grade urothelial carcinoma (LGUC/HGUC) or benign. Interobserver agreement w

SUBMITTER: de Ruiter BM 

PROVIDER: S-EPMC11283388 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature