High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.

ABSTRACT:

Introduction

Thiamine (Vitamin B1) is an essential micronutrient and is classically considered a co-factor in energy metabolism. The association between thiamine status and whole-body metabolism in critical illness has not been studied.

Objectives

To determine association between whole blood thiamine pyrophosphate (TPP) concentrations and plasma metabolites and connected metabolic pathways using high resolution metabolomics (HRM) in critically ill patients.

Methods

Cross-sectional study performed at Erciyes University Hospital, Kayseri, Turkey and Emory University, Atlanta, GA, USA. Participants were critically ill adults with an expected length of intensive care unit stay longer than 48 h and receiving chronic furosemide therapy. A total of 76 participants were inclu

SUBMITTER: Gundogan K 

PROVIDER: S-EPMC11283406 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature