Prevention of taxane chemotherapy-induced nail changes and peripheral neuropathy by application of extremity cooling: a prospective single-centre study with intrapatient comparison.

ABSTRACT:

Purpose

Common side effects of taxane chemotherapy are nail toxicity and peripheral neuropathy (CIPN) causing severe impact on the quality of life. Different methods of cryotherapy to prevent these side effects have been tested. We investigated the use of machine-controlled cooling of hands and feet to reduce nail toxicity and CIPN in patients receiving taxane chemotherapy.

Methods

Patients receiving Docetaxel (planned dose ≥ 300 mg/m²) or Paclitaxel (planned dose ≥ 720 mg/m² - ) in the adjuvant or palliative setting of different cancers were included. The dominant hand and foot were cooled to approximately 10 °C using the Hilotherapy machine. The contralateral hand and foot were used as intrapatient comparison. The primary endpoint was the occurrence o

SUBMITTER: Johnson K 

PROVIDER: S-EPMC11283420 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature