Bridge-to-transplant temporary mechanical circulatory support and risk of allosensitization.

ABSTRACT:

Introduction

Since the 2018 change in the US adult heart allocation policy, more patients are bridged-to-transplant on temporary mechanical circulatory support (tMCS). Previous studies indicate that durable left ventricular assist devices (LVAD) may lead to allosensitization. The goal of this study was to assess whether tMCS implantation is associated with changes in sensitization.

Methods

We included patients evaluated for heart transplants between 2015 and 2022 who had alloantibody measured before and after MCS implantation. Allosensitization was defined as development of new alloantibodies after tMCS implant.

Results

A total of 41 patients received tMCS before transplant. Nine (22.0%) patients developed alloantibodies following tMCS implantation: 3 (12.0%) in the i

SUBMITTER: Sideris K 

PROVIDER: S-EPMC11283677 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature