Association between amoxicillin administration and outcomes in critically ill patients with acute kidney injury.

ABSTRACT:

Purpose

This study assessed the effect of amoxicillin on outcomes in intensive care unit (ICU) patients with acute kidney injury (AKI), focusing on mortality rates and acute kidney disease (AKD) occurrence.

Materials and methods

We conducted a retrospective cohort analysis utilizing data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The study included intensive care unit patients diagnosed with AKI to assess the effects of post-admission amoxicillin administration on 30-day and 90-day mortality rates and acute kidney disease incidence. We employed Cox proportional hazards models, propensity score matching, and inverse probability of treatment weighting to control for potential confounders.

Results

Among 24,650 AKI patients, 676 (2.7%) re

SUBMITTER: Luo X 

PROVIDER: S-EPMC11284156 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature