The p75 neurotrophin receptor attenuates secondary thalamic damage after cortical infarction by promoting angiogenesis.

ABSTRACT:

Background

Angiogenesis is crucial in neuroprotection of secondary thalamic injury after cortical infarction. The p75 neurotrophin receptor (p75^NTR) plays a key role in activating angiogenesis. However, the effects of p75^NTR on angiogenesis in the thalamus after cortical infarction are largely unknown. Herein we investigate whether p75^NTR facilitates angiogenesis to attenuate secondary thalamic damage via activating hypoxia-inducible factor 1α (HIF-1α)/vascular endothelial growth factor (VEGF) pathway mediated by Von Hippel-Lindau (VHL) after distal middle cerebral artery occlusion (dMCAO).

Methods

The male rat model of dMCAO was established. The effects of p75^NTR on the angiogenesis was evaluated using RNA-sequencing, immunohistoc

SUBMITTER: Peng L 

PROVIDER: S-EPMC11284236 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature