Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants.

ABSTRACT:

Introduction

Preterm infants experience tremendous early life pain/stress during their neonatal intensive care unit (NICU) hospitalization, which impacts their neurodevelopmental outcomes. Mitochondrial function/dysfunction may interface between perinatal stress events and neurodevelopment. Nevertheless, the specific proteins or pathways linking mitochondrial functions to pain-induced neurodevelopmental outcomes in infants remain unidentified. Our study aims to investigate the associations among pain/stress, proteins associated with mitochondrial function/dysfunction, and neurobehavioral responses in preterm infants.

Methods

We conducted a prospective cohort study, enrolling 33 preterm infants between September 2017 and July 2022 at two affiliated NICUs located in Hartford a

SUBMITTER: Zhao T 

PROVIDER: S-EPMC11284246 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature