Prospective Study of Change in Skin Autofluorescence Over Time and Mortality in People Receiving Hemodialysis.

ABSTRACT: Elevated skin autofluorescence (SAF), a measure of tissue accumulation of advanced glycation end products (AGEs), is a strong predictor of all-cause and cardiovascular mortality in the hemodialysis population. However, prospective studies investigating the association between changes in SAF over time and mortality are scarce. We therefore aimed to investigate the prognostic value of SAF trend for predicting mortality in a hemodialysis population. We enrolled 120 patients on hemodialysis in a 5-year observational, prospective study. SAF was measured at baseline, 3, 6, 9, 12, and 24 months. Rate of change in SAF (i.e., SAF trend) was calculated using linear regression. Time to event was the number of days from baseline to death, kidney transplantation, or March 31, 2022. Mean age, mean basel

SUBMITTER: Viramontes-Horner D 

PROVIDER: S-EPMC11284442 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature