Modified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis.

ABSTRACT:

Background

The Gender, Age and Physiology (GAP) model is a simple mortality prediction tool in patients with idiopathic pulmonary fibrosis that uses demographic and physiological variables available at initial evaluation. White blood cell variables may have associations with idiopathic pulmonary fibrosis outcomes. We evaluated whether incorporating blood cell counts in modified GAP (cGAP) models would improve outcome prediction in patients with idiopathic pulmonary fibrosis.

Patients and methods

This retrospective analysis included pooled data from phase 3 randomised trials of pirfenidone in idiopathic pulmonary fibrosis (ASCEND, CAPACITY 004, CAPACITY 006). Study outcomes (disease progression, all-cause mortality, all-cause hospitalisation, respiratory-related hospitalisati

SUBMITTER: Kreuter M 

PROVIDER: S-EPMC11284599 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature