MRI Signature of α-Synuclein Pathology in Asymptomatic Stages and a Memory Clinic Population.

ABSTRACT:

Importance

The lack of an in vivo measure for α-synuclein (α-syn) pathology until recently has limited thorough characterization of its brain atrophy pattern, especially during early disease stages.

Objective

To assess the association of state-of-the-art cerebrospinal fluid (CSF) seed amplification assays (SAA) α-syn positivity (SAA α-syn+) with magnetic resonance imaging (MRI) structural measures, across the continuum from clinically unimpaired (CU) to cognitively impaired (CI) individuals, in 3 independent cohorts, and separately in CU and CI individuals, the latter reflecting a memory clinic population.

Design, setting, and participants

Cross-sectional data were used from the Swedish BioFINDER-2 study (inclusion, 2017-2023) as the discovery cohort and the Swedish B

SUBMITTER: Wisse LEM 

PROVIDER: S-EPMC11284633 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature