Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care.

ABSTRACT:

Importance

An accurate blood test for Alzheimer disease (AD) could streamline the diagnostic workup and treatment of AD.

Objective

To prospectively evaluate a clinically available AD blood test in primary care and secondary care using predefined biomarker cutoff values.

Design, setting, and participants

There were 1213 patients undergoing clinical evaluation due to cognitive symptoms who were examined between February 2020 and January 2024 in Sweden. The biomarker cutoff values had been established in an independent cohort and were applied to a primary care cohort (n = 307) and a secondary care cohort (n = 300); 1 plasma sample per patient was analyzed as part of a single batch for each cohort. The blood test was then evaluated prospectively in the primary care cohort

SUBMITTER: Palmqvist S 

PROVIDER: S-EPMC11284636 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature