Role of Cav2.3 (R-type) Calcium Channel in Pain and Analgesia: A Scoping Review.

ABSTRACT:

Background

Voltage-gated calcium channels (VGCCs) play an important role in pain development and maintenance. As Cav2.2 and Cav3.2 channels have been identified as potential drug targets for analgesics, the participation of Cav2.3 (that gives rise to R-type calcium currents) in pain and analgesia remains incompletely understood.

Objective

Identify the participation of Cav2.3 in pain and analgesia.

Methods

To map research in this area as well as to identify any existing gaps in knowledge on the potential role of Cav2.3 in pain signalling, we conducted this scoping review. We searched PubMed and SCOPUS databases, and 40 articles were included in this study. Besides, we organized the studies into 5 types of categories within the broader context of the role of Cav2.3 in p

SUBMITTER: de Amorim Ferreira M 

PROVIDER: S-EPMC11284728 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature