A Multipronged Bioengineering, Spectroscopic and Theoretical Approach in Unravelling the Excited-State Dynamics of the Archetype Mycosporine Amino Acid.

ABSTRACT: Mycosporine glycine (MyG) was produced by the fermentation of a purposely engineered bacterial strain and isolated from this sustainable source. The ultrafast spectroscopy of MyG was then investigated in its native, zwitterionic form (MyG_zwitter), via femtosecond transient electronic absorption spectroscopy. Complementary nonadiabatic (NAD) simulations suggest that, upon photoexcitation to the lowest excited singlet state (S₁), MyG_zwitter undergoes efficient nonradiative decay to repopulate the electronic ground state (S₀). We propose an initial ultrafast ring-twisting mechanism toward an S₁/S₀ conical intersection, followed by internal conversion to S₀ and subsequent vibrational cooling. This study illuminates th

SUBMITTER: Hymas M 

PROVIDER: S-EPMC11284840 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature