Modeling Poliovirus Transmission and Responses in New York State.

ABSTRACT:

Background

In July 2022, New York State (NYS) reported a case of paralytic polio in an unvaccinated young adult, and subsequent wastewater surveillance confirmed sustained local transmission of type 2 vaccine-derived poliovirus (VDPV2) in NYS with genetic linkage to the paralyzed patient.

Methods

We adapted an established poliovirus transmission and oral poliovirus vaccine evolution model to characterize dynamics of poliovirus transmission in NYS, including consideration of the immunization activities performed as part of the declared state of emergency.

Results

Despite sustained transmission of imported VDPV2 in NYS involving potentially thousands of individuals (depending on seasonality, population structure, and mixing assumptions) in 2022, the expected number of a

SUBMITTER: Thompson KM 

PROVIDER: S-EPMC11284859 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature