Combination cell therapy leads to clonal deletion of donor-specific T cells in kidney transplant recipients.

ABSTRACT:

Background

Induction of donor-specific tolerance is a promising approach to achieve long-term graft patency in transplantation with little to no maintenance immunosuppression. Changes to the recipient's T cell receptor (TCR) repertoire are understood to play a pivotal role in the establishment of a robust state of tolerance in chimerism-based transplantation protocols.

Methods

We investigated changes to the TCR repertoires of patients participating in an ongoing prospective, controlled, phase I/IIa trial designed to evaluate the safety and efficacy of combination cell therapy in living donor kidney transplantation. Using high-throughput sequencing, we characterized the repertoires of six kidney recipients who also received bone marrow from the same donor (CKBMT), together wi

SUBMITTER: David AF 

PROVIDER: S-EPMC11284950 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature