Variability of individual platelet reactivity over time in patients treated with clopidogrel: insights from the ELEVATE-TIMI 56 trial.

ABSTRACT:

Background

The degree of antiplatelet response to clopidogrel has been associated with clinical outcomes. Studies have investigated whether adjustment of antiplatelet therapies based on a single platelet function test is beneficial.

Objectives

The aim of the study was to test the stability of platelet reactivity measurements over time among patients treated with standard and double doses of clopidogrel.

Methods

The ELEVATE-TIMI 56 (Escalating Clopidogrel by Involving a Genetic Strategy-Thrombolysis In Myocardial Infarction 56) investigators genotyped 333 patients with coronary artery disease and randomized them to various clopidogrel regimens. Patients with at least 2 platelet function results on the same maintenance dose of clopidogrel (75 mg or 150 mg) were analyzed

SUBMITTER: Hochholzer W 

PROVIDER: S-EPMC11284982 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature