An O-methylflavone from Artemisia afra kills non-replicating hypoxic Mycobacterium tuberculosis.

ABSTRACT:

Ethnopharmacological relevance

African wormwood (Artemisia afra Jacq. ex Willd.) has been used traditionally in southern Africa to treat illnesses causing fever and was recently shown to possess anti-tuberculosis activity. As tuberculosis is an endemic cause of fever in southern Africa, this suggests that the anti-tubercular activity of A. afra may have contributed to its traditional medicinal use.

Aim of the study

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a deadly and debilitating disease globally affecting millions annually. Emerging drug-resistant Mtb strains endanger the efficacy of the current therapies employed to treat tuberculosis; therefore, there is an urgent need to develop novel drugs to combat this disease. Given the reported activity of A. af

SUBMITTER: Kellogg JJ 

PROVIDER: S-EPMC11285045 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature