Blood glucose outcomes of anti-retroviral therapy naive Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks.

ABSTRACT:

Background

The Uganda ministry of Health recommends frequent blood glucose monitoring for the first six months on dolutegravir, in people with HIV (PWH) having pre-diabetes mellitus (pre-DM). We sought to determine if indeed PWH with pre-diabetes started on dolutegravir had worse blood glucose outcomes at 48 weeks compared to those with normal blood glucose.

Methods

In this matched cohort study, we compared 44 PWH with pre-DM and 88 PWH with normal blood glucose at baseline. The primary outcome was change in mean fasting blood glucose (FBG) from baseline to week 48 and 2-hour blood glucose (2hBG) from baseline to week 36 compared between the two groups.

Results

There was significant increase in FBG in PWH with normal blood glucose (mean change in FBG(FBG): 3.9 mg/dl,

SUBMITTER: Mulindwa F 

PROVIDER: S-EPMC11285129 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature