Life-Course Pathways to Exceptional Longevity: Evidence From the Lothian Birth Cohort of 1921.

ABSTRACT:

Background

Longevity, a hallmark of successful aging, is a multifactorial trait with influences from birth onwards. However, limited evidence exists on the pathways linking diverse life-course exposures to longevity, especially within a single cohort.

Methods

We investigated associations between life-course factors and longevity among community-dwelling adults aged 79 (N = 547) from the Lothian Birth Cohort 1921 with a mortality follow-up of 24 years. Cox proportional hazards and structural equation (path) models were used to explore how factors from early life (social class, childhood intelligence quotient [IQ], education), midlife (social class), and later life (health, lifestyle, psychosocial well-being), as well as sex, personality, and apolipoprotein E e4 status, influe

SUBMITTER: Corley J 

PROVIDER: S-EPMC11285160 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature