Folate-mediated transgenerational inheritance of sperm DNA methylation patterns correlate with spinal axon regeneration.

ABSTRACT: In mammals, the molecular mechanisms underlying transgenerational inheritance of phenotypic traits in serial generations of progeny after ancestral environmental exposures, without variation in DNA sequence, remain elusive. We've recently described transmission of a beneficial trait in rats and mice, in which F0 supplementation of methyl donors, including folic acid, generates enhanced axon regeneration after sharp spinal cord injury in untreated F1 to F3 progeny linked to differential DNA methylation levels in spinal cord tissue. To test whether the transgenerational effect of folic acid is transmitted via the germline, we performed whole-genome methylation sequencing on sperm DNA from F0 mice treated with either folic acid or vehicle control, and their F1, F2, and F3 untreated progeny. T

SUBMITTER: Madrid A 

PROVIDER: S-EPMC11285217 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature