IGF1R signaling induces epithelial-mesenchymal plasticity via ITGAV in cutaneous carcinoma.

ABSTRACT:

Background

Early cutaneous squamous cell carcinomas (cSCCs) generally show epithelial differentiation features and good prognosis, whereas advanced cSCCs present mesenchymal traits associated with tumor relapse, metastasis, and poor survival. Currently, the mechanisms involved in cSCC progression are unclear, and the established markers are suboptimal for accurately predicting the clinical course of the disease.

Methods

Using a mouse model of cSCC progression, expression microarray analysis, immunofluorescence and flow cytometry assays, we have identified a prognostic biomarker of tumor relapse, which has been evaluated in a cohort of cSCC patient samples. Phosphoproteomic analysis have revealed signaling pathways induced in epithelial plastic cancer cells that promote epith

SUBMITTER: Lopez-Cerda M 

PROVIDER: S-EPMC11285232 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature