The obesity paradox and 90 day mortality in chronic critically ill patients: a cohort study using a large clinical database.

ABSTRACT:

Background

This study investigates the obesity paradox, where obesity is linked to lower mortality in certain patient groups, focusing on its impact on long-term mortality in chronic critically ill (CCI) patients.

Methods

We retrospectively analyzed CCI patients from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database's Intensive Care Unit, categorizing them into six groups based on Body Mass Index (BMI). Using stepwise multivariable Cox regression and restricted cubic spline models, we examined the association between BMI and 90 day mortality, accounting for confounding variables through subgroup analyses.

Results

The study included 1996 CCI patients, revealing a 90 day mortality of 34.12%. Overweight and obese patients exhibited significantly lowe

SUBMITTER: Xu D 

PROVIDER: S-EPMC11285416 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature