A multicenter prospective study to define the natural history of BK viral infections in kidney transplantation.

ABSTRACT:

Background

BK polyomavirus (BKV) can cause permanent loss of allograft function due to BKV-associated nephropathy (BKVN) in kidney transplant recipients. Besides immunosuppression reduction, there are no consistently effective interventions for BKV infection. Study purpose was to define natural history of BKV infection, identify risk factors for BKV reactivation and BKVN in kidney transplant recipients, and inform the design/conduct of future clinical trials of BKV-targeted therapeutics.

Methods

We conducted a multicenter prospective observational study of incident kidney transplant recipients at six U.S. transplant centers. Participants were monitored every 4 weeks for BKV reactivation and followed for up to 24 months post-transplant. We used regression models (logistic, su

SUBMITTER: Seifert ME 

PROVIDER: S-EPMC11285626 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature