Cerebrovascular lesion loads and accelerated brain aging: insights into the cognitive spectrum.

ABSTRACT:

Introduction

White matter hyperintensities (WMHs) and cerebral microbleeds are widespread among aging population and linked with cognitive deficits in mild cognitive impairment (MCI), vascular MCI (V-MCI), and Alzheimer's disease without (AD) or with a vascular component (V-AD). In this study, we aimed to investigate the association between brain age, which reflects global brain health, and cerebrovascular lesion load in the context of pathological aging in diverse forms of clinically-defined neurodegenerative conditions.

Methods

We computed brain-predicted age difference (brain-PAD: predicted brain age minus chronological age) in the Comprehensive Assessment of Neurodegeneration and Dementia cohort of the Canadian Consortium on Neurodegeneration in Aging including 70 cognit

SUBMITTER: Beheshti I 

PROVIDER: S-EPMC11285662 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature