Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.

ABSTRACT: Genetic variants play a crucial role in shaping the adaptive phenotypes associated with high-altitude populations. Nevertheless, a comprehensive understanding of the specific impacts of different environments associated with increasing altitudes on the natural selection of these genetic variants remains undetermined. Hence, this study aimed to identify genetic markers responsible for high-altitude adaptation with specific reference to different altitudes, majorly focussing on an altitude elevation range of ∼1500 m and a corresponding decrease of ≥5 % in ambient oxygen availability. We conducted a comprehensive genome-wide investigation (n = 192) followed by a validation study (n = 514) in low-altitude and three high-altitude populations (>2400 m) of Nubra village (NU) (3048 m), Sakti villa

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11285711 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature