Plasma proteomic biomarkers and the association between poor cardiovascular health and incident dementia: The UK Biobank study.

ABSTRACT:

Background

The study examined how plasma proteome indicators may explain the link between poor cardiovascular health (CVH) and dementia risk.

Methods

The present study involved 28,974 UK Biobank participants aged 50-74y at baseline (2006-2010) who were followed-up for ≤ 15 y for incidence of dementia. CVH was calculated using Life's Essential 8 (LE8) total scores. The scores were standardized and reverse coded to reflect poor CVH (LE8z_rev). OLINK proteomics was available on this sample (k = 1,463 plasma proteins). The study primarily tested the mediating effects of the plasma proteome in LE8z_rev-dementia effect. The total effect was decomposed into "mediation only" or pure indirect effect (PIE), "interaction only" or interaction referent (INTREF), "neither mediation nor in

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC11285716 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature