Reducing False-Positives in CT Perfusion Infarct Core Segmentation Using Contralateral Local Normalization.

ABSTRACT:

Background and purpose

The established global threshold of rCBF <30% for infarct core segmentation can lead to false-positives, as it does not account for the differences in blood flow between GM and WM and patient-individual factors, such as microangiopathy. To mitigate this problem, we suggest normalizing each voxel not only with a global reference value (ie, the median value of normally perfused tissue) but also with its local contralateral counterpart.

Materials and methods

We retrospectively enrolled 2830 CTP scans with suspected ischemic stroke, of which 335 showed obvious signs of microangiopathy. In addition to the conventional, global normalization, a local normalization was performed by dividing the rCBF maps with their mirrored and smoothed counterpart, which sets

SUBMITTER: Rau A 

PROVIDER: S-EPMC11286109 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature