Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography.

ABSTRACT:

Background and purpose

Normal pressure hydrocephalus is a treatable cause of dementia associated with distinct mechanical property signatures in the brain as measured by MR elastography. In this study, we tested the hypothesis that specific anatomic features of normal pressure hydrocephalus are associated with unique mechanical property alterations. Then, we tested the hypothesis that summary measures of these mechanical signatures can be used to predict clinical outcomes.

Materials and methods

MR elastography and structural imaging were performed in 128 patients with suspected normal pressure hydrocephalus and 44 control participants. Patients were categorized into 4 subgroups based on their anatomic features. Surgery outcome was acquired for 68 patients. Voxelwise modeling

SUBMITTER: Karki P 

PROVIDER: S-EPMC11286123 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature