Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS.

ABSTRACT:

Background

To examine data quality and reproducibility using ISTHMUS, which has been implemented as the standardized MR spectroscopy sequence for the multi-site Healthy Brain and Child Development (HBCD) study.

Methods

ISTHMUS is the consecutive acquisition of short-TE PRESS (32 transients) and long-TE HERCULES (224 transients) data with dual-TE water reference scans. Voxels were positioned in the centrum semiovale, dorsal anterior cingulate cortex, posterior cingulate cortex and bilateral thalamus regions. After acquisition, ISTHMUS data were separated into the PRESS and HERCULES portions for analysis and modeled separately using Osprey. In vivo experiments were performed in 10 healthy volunteers (6 female; 29.5±6.6 years). Each volunteer underwent two scans on the same day

SUBMITTER: Hui SCN 

PROVIDER: S-EPMC11286357 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature