Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis.

ABSTRACT:

Objectives

Osteosarcoma (OS) is the primary bone tumor originating from transformed mesenchymal cells. It is unclear whether associations between specific circulating immune cells and OS are causal or due to bias. To clarify whether predicted genetically altered circulating immune cells are associated with OS development, we performed a two-sample Mendelian randomization (MR) analysis.

Methods

The genetic variants strongly associated with immune cell traits as instrumental variables (IVs) were used to perform MR analyses. The effect of specific immune cells on OS risk was measured using the summary statistics from the genome-wide association studies (GWAS).

Results

Our findings indicate that CD80 on CD62L+ myeloid dendritic cell and CD28-CD4-CD8- T-cell absolute count

SUBMITTER: Li L 

PROVIDER: S-EPMC11286390 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature