Association of modified dementia risk score with cerebrospinal fluid biomarkers and cognition in adults without dementia.

ABSTRACT:

Introduction

This study aimed to investigate the cognitive profile and prospective cognitive changes in non-demented adults with elevated Modified Dementia Risk Scores (MDRS), while also exploring the potential relationship between these associations and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology and neuroinflammation.

Methods

Within the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database, 994 participants without dementia were assessed on MDRS, CSF biomarkers and cognition. We examined the associations of the MDRS with CSF biomarkers and cognitive scores using linear regressions. Causal mediation analyses were conducted to analyze the associations among MDRS, brain pathologies, and cognition. The Alzheimer's Disease Neuroimaging Init

SUBMITTER: Li QY 

PROVIDER: S-EPMC11286572 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature