Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication.

ABSTRACT: Extracellular vesicles (EVs) serve as messengers for intercellular communication, yet the precise mechanisms by which recipient cells interpret EV messages remain incompletely understood. In this study, we explored how the origin of EVs, their protein cargo, and the recipient cell type influence the cellular response to EVs within an embryo implantation model. We treated two types of EVs to 6 different recipient cell types and expression of zinc finger protein 81 (ZNF81) gene expression in the recipient cells were quantified using quantitative polymerase chain reaction (qPCR). The proteomic contents of the EV cargos were also analyzed. The results showed that downregulation of the ZNF81 gene was a specific cellular response of receptive endometrial epithelial cells to trophoblast derived E

SUBMITTER: Dissanayake K 

PROVIDER: S-EPMC11286576 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature