Unveiling systemic responses in kidney transplantation: interplay between the allograft transcriptome and serum proteins.

ABSTRACT: Immunity, as defined by systems biology, encompasses a holistic response throughout the body, characterized by intricate connections with various tissues and compartments. However, this concept has been rarely explored in kidney transplantation. In this proof-of-concept study, we investigated a direct association between the allograft phenotype and serum protein signatures. Time-matched samples of graft biopsies and blood serum were collected in a heterogeneous cohort of kidney-transplanted patients (n = 15) for bulk RNA sequencing and proteomics, respectively. RNA transcripts exhibit distinct and reproducible, coregulated gene networks with specific functional profiles. We measured 159 serum proteins and investigated correlations with gene expression networks. Two opposing axes-one

SUBMITTER: Buscher K 

PROVIDER: S-EPMC11286594 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature