Effects of different combinations of mechanical loading intensity, duration, and frequency on the articular cartilage in mice.

ABSTRACT:

Background

Understanding how healthy articular cartilage responds to mechanical loading is critical. Moderate mechanical loading has positive effects on the cartilage, such as maintaining cartilage homeostasis. The degree of mechanical loading is determined by a combination of intensity, frequency, and duration; however, the best combination of these parameters for knee cartilage remains unclear. This study aimed to determine which combination of intensity, frequency, and duration provides the best mechanical loading on healthy knee articular cartilage in vitro and in vivo.

Methods and results

In this study, 33 male mice were used. Chondrocytes isolated from mouse knee joints were subjected to different cyclic tensile strains (CTSs) and assessed by measuring the expression o

SUBMITTER: Wakimoto Y 

PROVIDER: S-EPMC11286701 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature