The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.

ABSTRACT: Acute kidney injury (AKI) is a major worldwide health concern that currently lacks effective medical treatments. PSMP is a damage-induced chemotactic cytokine that acts as a ligand of CCR2 and has an unknown role in AKI. We have observed a significant increase in PSMP levels in the renal tissue, urine, and plasma of patients with AKI. PSMP deficiency improved kidney function and decreased tubular damage and inflammation in AKI mouse models induced by kidney ischemia-reperfusion injury, glycerol, and cisplatin. Single-cell RNA sequencing analysis revealed that Ly6C^hi or F4/80^lo infiltrated macrophages (IMs) were a major group of proinflammatory macrophages with strong CCR2 expression in AKI. We observed that PSMP deficiency decreased CCR2⁺Ly6C^hi o

SUBMITTER: Song Z 

PROVIDER: S-EPMC11286806 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature