Effects of Hydroxyapatite-Containing Toothpastes on Some Caries-Related Variables: A Randomised Clinical Trial.

ABSTRACT:

Objectives

This randomised clinical trial was designed and carried out with the aim to evaluate the capacity of fluoride-substituted hydroxyapatite (HAF) toothpaste to modulate oral microflora composition and biofilm acidogenicity in schoolchildren.

Methods

In all, 610 children (4 to 5 and 6 to 7 years) were enrolled. Four toothpastes were randomly administered during 24 months: 2 contained fluoride-substituted hydroxyapatite (HAF₁₀₀₀ and HAF₁₄₅₀; 1000 and 1450 ppmF) and magnesium-, strontium-, and carbonate-substituted hydroxyapatite in a chitosan matrix, and 2 were monofluorophosphate fluoridated toothpastes (F₁₀₀₀ and F₁₄₅₀; 1000 and 1450 ppmF). Caries lesions were assessed by International Caries Detection and Assessment System

SUBMITTER: Campus G 

PROVIDER: S-EPMC11287134 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature