Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells.

ABSTRACT: Crosstalk between metabolism and circadian rhythms is a fundamental building block of multicellular life, and disruption of this reciprocal communication could be relevant to disease. Here, we investigated whether maintenance of circadian rhythms depends on specific metabolic pathways, particularly in the context of cancer. We found that in adult mouse fibroblasts, ATP levels were a major contributor to signal from a clock gene luciferase reporter, although not necessarily to the strength of circadian cycling. In contrast, we identified significant metabolic control of circadian function across a series of pancreatic adenocarcinoma cell lines. Metabolic profiling of congenic tumor cell clones revealed substantial diversity among these lines that we used to identify clones to generate circa

SUBMITTER: Iascone DM 

PROVIDER: S-EPMC11287162 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature