Haemodynamic implications of VA-ECMO vs. VA-ECMO plus Impella CP for cardiogenic shock in a large animal model.

ABSTRACT:

Aims

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with profound left ventricular (LV) failure is associated with inadequate LV emptying. To unload the LV, VA-ECMO can be combined with Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared with VA-ECMO in a porcine model of cardiogenic shock (CS).

Methods and results

Land-race pigs (weight 70 kg) were instrumented, including a LV conductance catheter and a carotid artery Doppler flow probe. CS was induced with embolization in the left main coronary artery. CS was defined as reduction of ≥50% in cardiac output or mixed oxygen saturation (SvO₂) or a SvO₂ < 30%. At CS VA-ECMO was initiated and embolization was continued until arterial pulse pressure was <10 mm

SUBMITTER: Frederiksen PH 

PROVIDER: S-EPMC11287291 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature