Renal ultrasonography predicts worsening renal function in patients with heart failure under tolvaptan administration.

ABSTRACT:

Aims

Renal dysfunction in patients with chronic heart failure predicts a poor prognosis. Tolvaptan has a diuretic effect in patients with chronic kidney disease and heart failure without adverse effects on renal function. We aimed to determine the effects of tolvaptan and predictors of worsening renal function in patients with heart failure.

Methods and results

This post hoc analysis was a sub-analysis of a single-centre prospectively randomized trial on the early and short-term tolvaptan administration. We enrolled 201 participants with decompensated heart failure between January 2014 and March 2019 (early group, n = 104; age: 79.0 ± 12.8 years; late group, n = 97; age: 80.3 ± 10.8 years). Renal ultrasonography was performed before and after the administration of tolvaptan.

SUBMITTER: Tanaka N 

PROVIDER: S-EPMC11287302 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature