Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor: An Open-Label Clinical Trial.

ABSTRACT:

Importance

Unilateral magnetic resonance-guided focused ultrasound ablation of ventralis intermedius nucleus of the thalamus for essential tremor reduces tremor on 1 side, but untreated contralateral or midline symptoms remain limiting for some patients. Historically, bilateral lesioning produced unacceptable risks and was supplanted by deep brain stimulation; increasing acceptance of unilateral focused ultrasound lesioning has led to interest in a bilateral option.

Objective

To evaluate the safety and efficacy of staged, bilateral focused ultrasound thalamotomy.

Design, setting, and participants

This prospective, open-label, multicenter trial treated patients with essential tremor from July 2020 to October 2021, with a 12-month follow-up, at 7 US academic medical cen

SUBMITTER: Kaplitt MG 

PROVIDER: S-EPMC11287440 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature