Fecal Microbiota Transplantation for Treatment of Parkinson Disease: A Randomized Clinical Trial.

ABSTRACT:

Importance

Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) has shown promising effects in preclinical PD models.

Objective

To assess the safety and symptomatic efficacy of colonic single-dose anaerobically prepared FMT.

Design, setting, and participants

This was a double-blind, placebo-controlled, randomized clinical trial conducted between November 2020 and June 2023 with a follow-up period of 12 months at 4 hospitals in Finland. Patients with PD aged 35 to 75 years in Hoehn & Yahr stage 1-3 with a mild to moderate symptom burden and dysbiosis of fecal microbiota were included. Of 229 patients screened, 48 were randomized and 47 received the intervention. One patient discontinued due to worsening of PD sy

SUBMITTER: Scheperjans F 

PROVIDER: S-EPMC11287445 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature