Intracoronary thrombolysis in ST-elevation myocardial infarction: a systematic review and meta-analysis.

ABSTRACT:

Background

Despite restoration of epicardial blood flow in acute ST-elevation myocardial infarction (STEMI), inadequate microcirculatory perfusion is common and portends a poor prognosis. Intracoronary (IC) thrombolytic therapy can reduce microvascular thrombotic burden; however, contemporary studies have produced conflicting outcomes.

Objectives

This meta-analysis aims to evaluate the efficacy and safety of adjunctive IC thrombolytic therapy at the time of primary percutaneous coronary intervention (PCI) among patients with STEMI.

Methods

Comprehensive literature search of six electronic databases identified relevant randomised controlled trials. The primary outcome was major adverse cardiac events (MACE). The pooled risk ratio (RR) and weighted mean difference (WMD)

SUBMITTER: Rehan R 

PROVIDER: S-EPMC11287581 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature