Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes.

ABSTRACT:

Objectives

Osteoarthritis is a complex disease with a huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organisation in three-dimensional (3D) space is essential for identifying long-range contacts between distant genomic features (e.g., between genes and regulatory elements), in a tissue-specific manner. Here, we generate the first whole genome chromosome conformation analysis (Hi-C) map of primary osteoarthritis chondrocytes and identify novel candidate effector genes for the disease.

Methods

Primary chondrocytes collected from 8 patients with knee osteoarthritis underwent Hi-C analysis t

SUBMITTER: Bittner N 

PROVIDER: S-EPMC11287644 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature