Identification of an Allele-Specific Transcription Factor Binding Interaction that May Regulate PLA2G2A Gene Expression.

ABSTRACT: The secreted phospholipase A₂ (sPLA₂) isoform, sPLA₂-IIA, has been implicated in a variety of diseases and conditions, including bacteremia, cardiovascular disease, COVID-19, sepsis, adult respiratory distress syndrome, and certain cancers. Given its significant role in these conditions, understanding the regulatory mechanisms impacting its levels is crucial. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs), including rs11573156, that are associated with circulating levels of sPLA₂-IIA. The work in the manuscript leveraged 4 publicly available datasets to investigate the mechanism by which rs11573156 influences sPLA₂-IIA levels via bioinformatics and modeling analysis. Through genoty

SUBMITTER: Hara A 

PROVIDER: S-EPMC11287738 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature