Short- and long-term impact of aspirin cessation in older adults: a target trial emulation.

ABSTRACT:

Background

The net benefit of aspirin cessation in older adults remains uncertain. This study aimed to use observational data to emulate a randomized trial of aspirin cessation versus continuation in older adults without cardiovascular disease (CVD).

Methods

Post hoc analysis using a target trial emulation framework applied to the immediate post-trial period (2017-2021) of a study of low-dose aspirin initiation in adults aged ≥ 70 years (ASPREE; NCT01038583). Participants from Australia and the USA were included if they were free of CVD at the start of the post-trial intervention period (time zero, T0) and had been taking open-label or randomized aspirin immediately before T0. The two groups in the target trial were as follows: aspirin cessation (participants who were taking

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11287830 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature