Demystifying BRAF Mutation Status in Colorectal Liver Metastases : A Multi-institutional, Collaborative Approach to 6 Open Clinical Questions.

ABSTRACT:

Objective

To investigate the clinical implications of BRAF -mutated (mut BRAF ) colorectal liver metastases (CRLMs).

Background

The clinical implications of mut BRAF status in CRLMs are largely unknown.

Methods

Patients undergoing resection for mut BRAF CRLM were identified from prospectively maintained registries of the collaborating institutions. Overall survival (OS) and recurrence-free survival (RFS) were compared among patients with V600E versus non-V600E mutations, KRAS/BRAF comutation versus mut BRAF alone, microsatellite stability status (Microsatellite Stable (MSS) vs instable (MSI-high)), upfront resectable versus converted tumors, extrahepatic versus liver-limited disease, and intrahepatic recurrence treated with repeat hepatectomy versus nonoperative manag

SUBMITTER: Margonis GA 

PROVIDER: S-EPMC11287877 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature