MicroRNA-19a-3p inhibits endothelial dysfunction in atherosclerosis by targeting JCAD.

ABSTRACT:

Objective

To examine the influences and mechanisms of MicroRNA-19a-3p (miR-19a-3p) on endothelial dysfunction in atherosclerosis.

Methods

An analysis of miR-19a expression was carried out using the Gene Expression Omnibus (GEO) database. The effect of miR-19a-3p on endothelial function in HUVECs was evaluated by miR-19a-3p overexpression under TNF-α treatment. Luciferase assays were performed to explore the potential target genes. Overexpression of junctional protein associated with coronary artery disease (JCAD) was used to examine the effects of miR-19a-3p on cell adhesion, and proliferation.

Results

MiR-19a-3p expression in endothelial cells decreased after exposure to TNF-α and/or oscillatory flow, consistent with the expression change of miR-19a-3p found in ather

SUBMITTER: Luo J 

PROVIDER: S-EPMC11287888 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature